... ion of the analyte (“precursor” or “parent” ion) is selectively passed by the first MS stage (e.g., quadrupole analyzer operated at unit mass resolution) and other ions are rejected, followed by collisional activation by an inert gas in ...
Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
... order to produce accurate structure-activity relationships (SAR) and ... diversity array that was synthesized using parallel (combinatorial) ... 18.1. Introduction 18.2. Fundamentals of Integrity and Purity 18.3. Integrity and Purity Effects.
Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs
... pKa values of mono and difluorinated piperidines F F F F F F N H N H N H N H pKa = 11.1 pKa = 9.3 pKa = 9.4 pKa = 7.4 pKa = 8.5 figure 19.5 Fluoro-substitution to lower amine basicity. observed with decreasing pKa . Thus, the B/P ratios ...
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